approach
The science of probiotics demands precision. In collaboration with leading scientists and research partners from around the world, we develop research-backed probiotics for outcomes across gastrointestinal, dermatological, oral, pediatric, and nutritional health.
For humans, by science.
Our process starts with microbial strain validation through biofermentation, stabilization, scale-up, and clinical research.
Whole body health, made possible by your microbiome
+8K of satisfied users
01
strain
Probiotic Strain Validation
Our strain bank consists of probiotic strains with extensive mechanistic and clinical data generated at academic institutions and research partners around the world—including Italy, Spain, Belgium, US, and Japan. Our strains are deposited in the American Type Culture Collection (ATCC).
Research-Derived Dosage
We select our strains based on robust clinical and mechanistic research, and preserve the biologically active dose of each strain in our product. Further, we ensure that the full dosage of live and active bacteria is delivered at or above label claim throughout the entire shelf life and under even the most destructive shipping temperatures.
02
biofermentation
Biofermentation
This—a metabolic process used by bacteria to generate energy for cell growth and multiplication—is how we culture our probiotic strains. Bacteria are sensitive. They must be cultured with care to ensure viability. We optimize biofermentation conditions for pH, strain purity, temperature, and 28 other factors.
03
validation
Flow Cytometry
During this process, cells are selectively tagged with fluorescent ‘markers’ and counted by a laser as they pass through a tube. In testing for AFU (Active Fluorescent Units), flow cytometry is used to calculate a more precise measurement of all viable, injured, and dead probiotic cells, including ones that are efficacious but not necessarily culturable (and therefore, would not be counted in a traditional plated colony forming units (CFU) measurement—what you’re probably used to seeing on probiotics labels).
Whole-genome Sequencing
Our probiotics are among the first to undergo end-to-end, whole-genome testing—the application of nanopore and shotgun sequencing of microbial DNA to genetically validate each strain and species.
Clinical Research
While we start with individual clinically and scientifically studied probiotic strains, we also validate our products through clinical research on the full formulation in double-blind, randomized, and controlled trials.
In 2020, we began conducting two trials, the first to assess the clinical effects of our DS-01™ in treating Irritable Bowel Syndrome (IBS), and the second under Health Canada approval to study the DS-01™ and its impact on post-antibiotic recovery.
04
testing
THYME Biome
During this process, cells are selectively tagged with fluorescent ‘markers’ and counted by a laser as they pass through a tube. In testing for AFU (Active Fluorescent Units), flow cytometry is used to calculate a more precise measurement of all viable, injured, and dead probiotic cells, including ones that are efficacious but not necessarily culturable (and therefore, would not be counted in a traditional plated colony forming units (CFU) measurement—what you’re probably used to seeing on probiotics labels).
team
We're an award-winning multidisciplinary team based in Philadelphia with a passion for creating innovative architecture. We work with businesses and people to create a more beautiful world.
Consectetur adipiscing elit. Etiam id mi faucibus, malesuada quam eget, facilisis turpis. Quisque ac purus erat.
Donec id pharetra tellus, vitae vehicula dolor. Aenean leo lorem, tempor vel mauris in, interdum fringilla erat. Nam auctor sodales dapibus. Ut et nibh sed neque lobortis mollis. Cras mauris tellus, ornare sed vestibulum eu, sagittis vitae justo. Vivamus pellentesque augue in orci commodo dignissim. Fusce id mi lacus.
Nullam ultricies mollis lorem, ac gravida diam pretium eget. Ut porttitor scelerisque lacus, a fringilla felis blandit sed.
Consectetur adipiscing elit. Etiam id mi faucibus, malesuada quam eget, facilisis turpis. Quisque ac purus erat.Donec id pharetra tellus, vitae vehicula dolor. Aenean leo lorem, tempor vel mauris in, interdum fringilla erat.
Nam auctor sodales dapibus. Ut et nibh sed neque lobortis mollis. Cras mauris tellus, ornare sed vestibulum eu, sagittis vitae justo. Vivamus pellentesque augue in orci commodo dignissim. Fusce id mi lacus.
Nullam ultricies mollis lorem, ac gravida diam pretium eget. Ut porttitor scelerisque lacus, a fringilla felis blandit sed.
Quisque elit nisl, varius nec ullamcorper eget, egestas vitae mi. Nam hendrerit eros a sagittis tempus. Mauris hendrerit hendrerit consequat. Nunc eget dui pulvinar, auctor neque sed, convallis ipsum. Fusce sagittis, dui a malesuada ullamcorper, nulla dolor interdum ipsum.
Ac condimentum eros lacus vestibulum nunc. Nunc maximus, massa et dictum dictum, risus massa dignissim nisl, at vestibulum ligula ante id metus. Morbi fringilla rhoncus porta.
Etiam nulla velit, pharetra vel leo a, pretium rhoncus eros. Fusce eu hendrerit ipsum, vitae volutpat dui. Nunc eget mi tincidunt, luctus turpis at, pharetra diam. Nam sit amet purus cursus, rhoncus nibh nec, volutpat purus. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Vestibulum id iaculis velit, vitae faucibus augue. In quis lectus nisi.
Etiam nulla velit, pharetra vel leo a, pretium rhoncus eros. Fusce eu hendrerit ipsum, vitae volutpat dui. Nunc eget mi tincidunt, luctus turpis at, pharetra diam. Nam sit amet purus cursus, rhoncus nibh nec, volutpat purus. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Vestibulum id iaculis velit, vitae faucibus augue. In quis lectus nisi.
